Ataxia

Causes

Appropriate Tests

Multiple sclerosis

MRI examination, CSF full examination

There is no single test that can definitively diagnose MS.  

Alcoholism, including

 

Wernicke-Korsakoff syndrome

 

Post-traumatic

 

Sensory

 

Polyneuropathy

See under Neuropathy.

Posterior column disorders

 

  • Tumour

 

  • Cervical spondylosis

 

  • Subacute combined degeneration

See under Vitamin B12 deficiency.

  • Tabes dorsalis

See under Syphilis.

Cerebellar

 

Infarct

 

Cerebellitis

 

Tumour

 

Paraneoplastic degeneration

Purkinje cell (YO) antibodies.

Genetic

 

Spinocerebellar ataxias

Autosomal dominant disorders - Molecular genetics (ie, Mikado Joseph disease).


Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Friedreich's ataxia

Molecular genetics.

Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Mitochondrial disorders

 

Hyperammonaemia

 

Organic acidaemias especially

 

  • Glutaric aciduria type I

 

Adrenomyeloneuropathy

Very long chain fatty acids.

Refsum disease

Phytanate.

Lysosomal storage diseases

Juvenile and adult forms.

Wilson's disease

Copper and Caeruloplasmin concentrations. Copper urine (24-hour) excretion.

Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Ataxia telangiectasia

Alpha-fetoprotein. Molecular genetics, if available.

Molecular genetics.

Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Lesch-Nyhan syndrome

Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Abetalipoproteinaemia

Apolipoprotein B. Vitamin E.

Tocopherol transfer protein deficiency

Vitamin E.

Infection, ie, Meningitis, Encephalitis, (viral, bacterial, fungal, parasitic and other, ie, Tuberculosis, Cryptococcal infection, Syphilis, etc)

Cerebrospinal fluid examination