Basophilia

Causes

Appropriate Tests

Basophilia is an uncommon finding
Causes include:

  • Myeloproliferative neoplasms (Chronic myeloid leukaemia, Essential thrombocythaemia, Polycythaemia vera, Primary myelofibrosis, Hypereosinophilic syndrome, Systemic mastocytosis)
  • Other haematological malignancies:
    • AML with t(6;9), AML with t(9;22); acute basophilic leukaemia
    • ALL with t(9;22)
    • Myelodysplastic syndromes.
  • Reactive causes:
    • Allergic and inflammatory conditions, eg, immediate hypersensitivity reactions, Ulcerative colitis, Rheumatoid arthritis (juvenile).
    • Endocrinopathies, eg, myxedema, administration of oestrogens, Hyperlipidaemia
  • Post-splenectomy

Review clinical findings;

Full blood count, especially Blood film morphology.

See also Leucocytosis, Table 4.

Other investigations can be instituted as appropriate depending on the clinical history, eg, appropriate immunoserological investigations for rheumatoid arthritis, appropriate endocrinological investigations as required.
 
The diagnosis of Myeloproliferative neoplasms may involve molecular tests such as BCR-ABL, JAK2 mutation analyses, and Bone biopsy with Flow cytometry, cytogenetic +/- FISH studies and molecular PCR investigations.

See also Eosinophilia.