Cold related disorders

Key Information

Appropriate Tests

Raynaud’s phenomenon

Clinical assessment in conjunction with Full blood count, Antinuclear Ab, Rheumatoid factor; Cryoglobulins, Complement components C3 and C4.

Primary (idiopathic)

 

Connective tissue diseases, especially

 

  • Scleroderma

 

  • Mixed connective tissue disease

See under Connective tissue diseases.

  • SLE

 

Cryoglobulinaemia

 

Drugs, including

 

  • Beta blockers

 

  • Ergot derivatives

 

Chronic arterial insufficiency

 

Occupational - vibrating tools

 

Occult carcinoma

 

Cold antibody haemolysis

See under Autoimmune haemolysis.

Acrocyanosis

Clinical assessment, Cryoglobulins, Full blood count, Protein, and Protein electrophoresis.

Cryoglobulinaemia

 

Connective tissue diseases

 

Cold antibody haemolysis

See under Autoimmune haemolysis.

Cold urticaria

Clinical assessment. Full blood count, Antinuclear Ab, Epstein-Barr virus serology, Complement components C3 and C4, Cold agglutinins, Cryoglobulins.

Urticaria

 

Cryoglobulinaemia

 

Livido reticularis

Clinical assessment; Full blood count, Antinuclear Ab, Cardiolipin Ab, Cryoglobulins, Protein, Protein electrophoresis; Beta 2 glycoprotein-1 antibodies.

Idiopathic

 

Connective tissue diseases

 

Phospholipid antibody syndrome

 

Cryoglobulinaemia

 

Vasculitis

 

Haemolysis

See 'Cold' antibody haemolysis under Autoimmune haemolysis.