Connective tissue diseases

Key Information

Appropriate Tests

 

These disorders are now termed systemic rheumatic diseases.

Full blood count, Blood film; C-Reactive protein and Erythrocyte sedimentation rate. Antinuclear Ab, DNA Ab and Extractable nuclear antigen Ab. Complement CH50 or CH100 and Complement components C3 and C4. Rheumatoid factor.

Rheumatoid arthritis

 

SLE

 

Mixed connective tissue disease

Extractable nuclear antigen Ab - RNP.

Sjögren syndrome

Extractable nuclear antigen Ab - Ro (S-SA), La (S-SB).

Scleroderma

Extractable nuclear antigen Ab - Scl 70.

CREST syndrome (limited scleroderma)

Centromere Ab.

Dermatomyositis / Polymyositis

Extractable nuclear antigen Ab - Jo-1 Ab. Consider investigation for underlying malignancy.