Crohn's disease

Complications + Associations

Appropriate Tests
 

Faeces MCS and antigen detection, Ova cysts parasites faeces, to exclude infection as the cause of prolonged diarrhoea.

Biopsy of the involved area.

Colorectal biopsy, Faecal calprotectin, Full blood count, Blood film. Protein, and Albumin; plasma or serum are useful for monitoring disease activity.

Crohn’s disease may present with a gastrointestinal or systemic complication.

Gastrointestinal complications

 

Malabsorption

Hypoalbuminaemia.

Fistulae

 

Bowel obstruction

 

Peri-anal fistula/abscess

Lesion biopsy to establish diagnosis and to exclude other conditions.

Systemic complications + associations

 

Amyloidosis

 

Anaemia, related to

 

  • Iron deficiency

 

  • Anaemia of chronic disease

 

  • Vitamin B12 deficiency

 

Treatment

 

Ankylosing spondylitis

 

Erythema nodosum

 

Hepatobiliary disease, including

 

  • Sclerosing cholangitis

See Cholestasis.

  • Autoimmune hepatitis

See under Hepatitis.

  • Cirrhosis

 

Splenic atrophy/absence

 

Treatment complications

 

Anaemia, especially

 

  • Salicylazosulphapyridine

See:

  • Drug-induced oxidative haemolysis under Haemolysis.
  • Drugs (may impair folate absorption) under Folate deficiency.

Corticosteroid excess