Diabetes insipidus

Causes

Appropriate Tests

 

In the appropriate clinical context, the diagnosis can be established from serum and Osmolality urine and Sodium urine. Plasma Antidiuretic hormone assay may be sometimes be used.

If necessary, a water deprivation test provides the definitive diagnosis, but it must be performed as a hospital procedure under medical supervision, this may include measurement of antidiurectic hormone (Vasopressin).

Electrolytes, Creatinine, Urea. Monitoring is best performed by measurement of urine volume.

Hypothalamic/pituitary (central)

 

Tumour (primary/metastatic)

Trauma

Granuloma

  • Sarcoidosis

Pituitary ablation

Idiopathic

 

Nephrogenic

 

Congenital/familial

Drug-related, especially

  • Lithium therapy
  • Methoxyfluorane anaesthesia

Renal tubulo-interstitial disorders