Hepatic failure

Keywords: Liver failure

Key Information

Appropriate Tests

 

Bilirubin, Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, Gamma glutamyltransferase, Albumin, Glucose, Electrolytes, Creatinine, Urea. Full blood count, Platelet count, Blood film, Prothrombin time, APTT, Thrombin time, Fibrinogen assay, D Dimer (Fibrin degradation products).

Liver biopsy, if appropriate.

Acute/fulminant

Ammonia (plasma) may assist diagnosis, particularly if the patient is not jaundiced.

See also Hepatitis.

Infection, especially

  • Hepatitis A virus infection
  • Hepatitis B virus infection
  • Hepatitis C virus infection
  • Hepatitis D virus infection
  • Hepatitis E virus infection

 

Drugs, especially

  • Paracetamol (overdose)
  • Halothane
  • Isoniazid

 

Paracetamol level. See also Figure 2.

Hepatic venous occlusion

 

  • Budd-Chiari syndrome

 

Fatty liver of pregnancy

 

Reye's syndrome

 

Wilson's disease

 

Chronic

See Cirrhosis.