Hereditary spherocytosis

Manifestations

Appropriate Tests

Red cell membrane defect

Clinical assessment should include personal and family history of anaemia, neonatal jaundice in particular the need for phototherapy, jaundice and gall stones.

Full blood count, Reticulocyte count, Blood film, Bilirubin, Lactate dehydrogenase.

Direct antiglobulin test to exclude autoimmune haemolytic anaemia.

Autoimmune haemolysis test or Osmotic fragility may be useful if diagnosis uncertain.

Flow cytometry evaluation to asses Eosin-5-maleimide staining is diagnostic.
 
Family studies as appropriate.

Haemolysis

See also Haemolysis.

Splenomegaly

 

Cholelithiasis