Hirschsprung's disease

Manifestations

Appropriate Tests

Delayed passage of meconium

Clinical diagnosis, with diagnostic imaging; diagnosis must be confirmed by Colorectal biopsy.

Immunohistochemistry: fresh tissue must be submitted for acetyl cholinesterase immunohistochemistry not only for diagnosis but also for determining the level of aganglionosis segment during surgical procedure. Calretinin immunohistochemistry is also of utility for diagnostic purposes.

Constipation

Abdominal distension

 

Neuronal intestinal dysplasia - can mimic Hirschsprung's disease