Hypergammaglobulinaemia

Causes

Appropriate Tests

 

The reference interval for gamma globulin varies with age and between racial groups.

See Table 2.

Protein, Albumin; Protein electrophoresis, Immunoglobulins G, A, M, Full blood count, Blood film, C-Reactive protein, Free light chains, Liver function tests and Antinuclear Ab.

Polyclonal

 

Chronic bacterial infection

 

Chronic liver disease, especially

  • Cirrhosis
  • Autoimmune hepatitis

 

See under Hepatitis.

HIV infection

 

Systematic rheumatic disease, especially

  • Sjögren syndrome

 

Angioimmunoblastic lymphadenopathy

Direct antiglobulin test; Protein electrophoresis, IFE, Lymph node biopsy.

Tropical splenomegaly syndrome

 

Monoclonal

 

Paraproteinaemia

 

MGUS

See Monoclonal gammopathy of undetermined significance.

Plasma cell myeloma

 

Chronic lymphoproliferative disorders

See Lymphoproliferative disorders

References:

Undas et al. Thromb Haemost 2005; 1994: 907-915.

Lewis et al. BMJ 2005; 331: 1053-1056.