Hyperuricaemia

Causes

Appropriate Tests

 

The possibility of an underlying cause should be considered. Full blood count, Blood film, Creatinine, Urea.

Urate urine only occasionally required to distinguish between increased production and decreased renal clearance.

Monitoring should include Urate, Creatinine, Urea.

Increased urate production

 

Primary metabolic gout

See Gout

Myeloproliferative neoplasms

 

Tumour lysis syndrome, especially

  • Cytotoxic drug therapy

 

Haemolytic anaemia

See Haemolysis.

Type I glycogen storage disease

See under Glycogen storage diseases.

Lesch-Nyhan syndrome

 

Rhabdomyolysis

See under Myoglobinuria.

Decreased urate clearance

 

Renal failure

 

Pregnancy-induced hypertension (toxaemia)

Protein urine. See Hypertension.

Alcoholism

 

Drug-induced, especially

  • Thiazides
  • Salicylates

 

Dehydration

 

Ketoacidosis

 

Lactic acidosis

 

Lead nephropathy

See Lead poisoning.

References

See also Pathology Decision Support Tool: Hyperuricaemia - genetic causes