Iron toxicity

Manifestations

Appropriate Tests

Acute toxicity (oral or intravenous iron)

Iron studies must be performed urgently. See Table 3.

In suspected iron poisoning serum iron concentrations less than 55 µmol/L between 1 and 6 h post-ingestion do not usually produce any clinical problems.

Levels in the 55-310 µmol/L range are associated with clinically mild iron poisoning.

Concentrations greater than 310 µmol/L are associated with liver toxicity.

  • Vomiting

 

  • Shock

Creatinine, Urea.

  • Hyperglycaemia

Glucose.

  • Leucocytosis

Full blood count.

  • Anaphylaxis (parenteral iron preparations)

 

Chronic iron overload

See Hereditary haemochromatosis, Haemosiderosis.

Reference

Royal College of Pathologists of Australasia. Iron Studies Standardised Reporting Protocol. Sydney: RCPA, 2013.