Leucoerythroblastic anaemia

Causes

Appropriate Tests

 

Presence of nucleated red cells and early myeloid cells with or without anaemia.

See also Anaemia, Leukaemoid reaction, Neutrophilia with early myeloid cells (blood film).

Review clinical findings, Full blood count, Blood film, White cell count differential, Platelet count.

See Table 4.

Bone marrow infiltration

Bone marrow aspiration and trephine biopsy may be indicated especially where a primary haematological marrow disorder is suspected or where no evidence of primary tumour (especially carcinoma) can be found. In the presence of known tumour infiltration and type determined by other means, bone marrow examination may not be indicated.

  • Metastatic carcinoma

Bone marrow examination may be appropriate if the presence of metastatic disease is otherwise unclear, or if documentation is required.

  • Primary myelofibrosis

Bone marrow aspirate and trephine with cytogenetics/molecular studies where appropriate.

Severe infection, especially Septicaemia and Tuberculosis (disseminated)

 

Osteopetrosis

 

Marked bone marrow response, especially

A picture similar to leucoerythroblastic anaemia may be seen acutely, but the cause is usually obvious from the clinical and other haematological features.

  • Severe trauma/shock, especially response to
    acute blood loss

 

  • Acute haemolysis

Haemolysis

  • Recovery from marrow suppression