Lymphoma (classification)

Key Information

Appropriate Tests

WHO Classification of Lymphoid Neoplasms

See Lymphoma (non-Hodgkin), and Hodgkin lymphoma for appropriate tests.

This has replaced the REAL and Working Formulations. There is overlap between the leukaemias and lymphomas, as reflected in the classification.

Sub-classification requires concordance of clinical findings with Histology, Immunohistochemistry, Lymphocyte immunophenotyping, Cytogenetics - oncology and Molecular genetics.

Precursor B-cell neoplasm

 

Precursor B-lymphoblastic leukaemia/lymphoma

 

Mature (peripheral) B-cell neoplasms

 

Small lymphocytic lymphoma / Chronic lymphocytic leukaemia

 

Lymphoplasmacytic lymphoma / Waldenström's macroglobulinaemia

 

Splenic marginal zone lymphoma

 

Hairy cell leukaemia

 

Plasma cell myeloma / Plasmacytoma

 

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type

 

Follicular lymphoma

Three grades:

  1. <20-25% large cells or < 5 large cells per high-powered field;
  2. 20-50% large cells or 5-15 large cells per high-powered field; and
  3. >50% large cells or >15 large cells per high-powered field.

Mantle cell lymphoma

 

Diffuse large B-cell lymphoma

  • Mediastinal large B-cell lymphoma
  • Primary effusion lymphoma

 

Burkitt lymphoma/leukaemia

 

Precursor T-cell neoplasm

 

Precursor T-lymphoblastic leukaemia/lymphoma

 

Mature T-cell and NK-cell lymphomas

 

T-cell prolymphocytic leukaemia

 

T-cell granular lymphocytic leukaemia

 

Aggressive NK-cell leukaemia

 

Adult T-cell leukaemia/lymphoma (HTLV-1+)

 

Extra-nodal NK/T-cell lymphoma, nasal type

 

Enteropathy-type T-cell lymphoma

 

Hepatosplenic gamma-delta T-cell lymphoma

 

Subcutaneous panniculitis-like T-cell lymphoma

 

Mycosis fungoides/Sezary syndrome

 

Anaplastic large cell lymphoma, T/null cell, primary cutaneous type

 

Peripheral T-cell lymphoma not otherwise characterised

 

Angioimmunoblastic T-cell lymphoma

 

Anaplastic large cell lymphoma, T/null cell, primary systemic type

 

Hodgkin lymphoma

 

Nodular lymphocyte predominant Hodgkin lymphoma

 

Classical Hodgkin lymphoma

  • Nodular sclerosis Hodgkin lymphoma
  • Lymphocyte-rich classical Hodgkin lymphoma
  • Mixed cellularity Hodgkin lymphoma
  • Lymphocyte-depleted classical Hodgkin lymphoma