Malignant hyperthermia

Key Information

Appropriate Tests

 

Muscle biopsy. Screening with Creatine kinase is possible in some families, but false negatives may occur.

The definitive test is the caffeine-halothane contracture test, which is performed in only a few specialised centres.

Susceptibility for malignant hyperthermia is inherited as an autosomal dominant condition with incomplete penetrance. 

History of an uneventful anaesthetic does not exclude a subsequent attack.

Mutations may be present in the ryanodine receptor (RYR1) and CACNA1S genes.

Additional information about genetic tests may be available in RCPA Catalogue of Genetic Tests and Laboratories.

Association

 

  • Central core disease
  • Duchenne/Becker muscular dystrophy
  • Periodic paralysis
  • Mitochondrial myopathy
  • Myotonia congenita

 

Acute episode: Muscle rigidity, tachycardia, rapid increase in body temperature.

Electrolytes (potassium), Creatine kinase, Urea, Creatinine, Myoglobin urine, Blood gas arterial.

See also Disseminated intravascular coagulation.