Myeloproliferative neoplasms

Keywords: MPN, Myeloproliferative disorders

Key Information

Appropriate Tests

A group of related, clonal, stem cell disorders characterised by excessive production of erythrocytes and/or granulocytes and/or platelets, increased bone marrow fibrosis, splenomegaly and, often, hyperuricaemia.

They all have the potential for transformation to acute leukaemia. Please see individual clinical problem entries as listed below.

Myeloproliferative neoplasms (MPN) have been subclassified by the World Health Organization as follows:

See also Chronic leukaemia

Please see individual clinical problem entries as listed below:

 

Chronic myeloid leukaemia

 

Polycythaemia vera

 

Essential thrombocythaemia (ET)

 

Primary myelofibrosis

 

Chronic eosinophilic leukaemia

 

Chronic neutrophilic leukaemia

 

Atypical chronic myeloid leukemia

 

Chronic myeloproliferative disease - unclassifiable