Neonatal bleeding

Key Information

Appropriate Tests

 

Full blood count, Blood film.

See also Bleeding disorders

Thrombocytopenia

 

Immune

 

Maternal ITP, including

  • SLE / other autoimmune disorders

Maternal Platelet count, however fetal/neonatal thrombocytopenia may occur even when the maternal platelet count is normal.

Platelet Ab tests on maternal serum may be informative.

Alloimmune

Platelet antigen testing of parents; Platelet Ab tests - consult haematopathologist.

Non-immune

 

Prematurity

 

Intra-uterine infection, especially

  • Cytomegalovirus infection
  • Herpes simplex virus infection
  • Rubella
  • Syphilis
  • Toxoplasmosis

 

Drug-related, especially

  • Maternal thiazides

 

DIC, especially with

 

Congenital syndromes

 

Prematurity

 

Neonatal sepsis

 

Severe hypoxia

 

Haemorrhagic disease of the newborn

Prothrombin time, APTT.

See also Vitamin K deficiency.

Inherited bleeding disorders

Severe inherited disorders of haemostasis may occasionally present in the neonatal period; see under Bleeding disorders.