Parvovirus B19 infection

Presentations

Appropriate Tests

 

Parvovirus serotype B19 is responsible for clinically significant infections and sequelae - Parvovirus B19 Ab.

Patients with persistent B19 infections may not have antibodies; diagnosis of persistent infection requires virus detection in serum, cells or synovial fluid (research laboratories only).

Erythema infectiosum (Fifth disease)

Testing usually not necessary.

Subacute polyarthritis

 

Hydrops fetalis

 

Pure red cell aplasia

Full blood count; Bone marrow aspiration may be indicated.

See Aplastic anaemia

Transient aplastic crisis

In patients with chronic haemolysis eg, Sickle cell disorders, Hereditary spherocytosis, Thalassaemia.

See Haemolysis

Transient erythroblastopaenia of childhood

 

Chronic bone marrow aplasia

Parvovirus B19 can cause marrow aplasia in patients with immunodeficiency, especially in those with acute leukaemia (lymphoblastic), congenital immunodeficiency states, AIDS and post-organ transplantation.

See Immunodeficiency

Full blood count; Bone marrow aspiration.