Platelet disorders

Key Information

Appropriate Tests

Quantitative

See Thrombocytopenia and Thrombocytosis.

Qualitative

 

Acquired platelet dysfunction

 

Medications:

Antiplatelet agents including aspirin, other NSAID, dipyridamole, P2Y12 receptor antagonists, such as clopidogrel, GPIIb/IIIa receptor antagonists

See under Bleeding disorders - acquired bleeding disorders.

Myeloproliferative neoplasms

  • Essential thrombocythaemia
  • Primary myelofibrosis

 

Paraproteinaemia

 

Renal failure

 

Inherited platelet dysfunction

See under Bleeding disorders - inherited bleeding disorders

Giant platelet disorders

 

Bernard Soulier syndrome- defect in GPIb/IX/V receptor

Full blood count: thrombocytopenia

Blood film: large platelets

Platelet aggregometry

Gray platelet syndrome- deficiency of alpha granules

Full blood count: thrombocytopenia

Blood film: gray platelets

Platelet aggregometry

May-Hegglin anomaly

Full blood count: thrombocytopenia

Blood film: neutrophil inclusions (Dohle like bodies)

Type 2B von Willebrand disease

Full blood count: normal platelet count

Blood film: normal morphology

Platelet aggregometry

von Willebrand disease testing

Small platelet disorders

 

Wiskott Aldrich syndrome

Full blood count: thrombocytopenia

Blood film: small platelets

Other platelet disorders

 

Storage pool disorders – deficiency in dense granules

Full blood count: normal platelet count

Platelet aggregometry

Glanzmann thrombasthenia – defect in GPIIb/IIIa receptor

Full blood count: normal platelet count

Platelet aggregometry