Polyglandular autoimmune syndrome

Key Information

Appropriate Tests

 

Tissue specific autoantibodies are of use in predicting future organ failure

Type I

Molecular genetics - genetic disorders.

Chronic mucocutaneous candidiasis

See Candidiasis

Hypoparathyroidism

 

Adrenocortical insufficiency

 

Gonadal hypofunction

See Testicular failure and Autoimmune ovarian failure under Amenorrhoea.

Type II

 

Multiple endocrine failure including

Associated with Thyrogastric cluster of autoimmune diseases. HLA B27 typing of occasional use.

  • Adrenocortical insufficiency

 

  • Hypoparathyroidism

 

  • Hypothyroidism

 

  • Hypopituitarism

 

  • Gonadal hypofunction

See Testicular failure and Autoimmune ovarian failure under Amenorrhoea.