Precocious pseudo-puberty

Causes

Appropriate Tests

 

Sexual maturation prior to 8 years (female) or 10 years (male); gonadal development remains consistent with chronological age.

See also Precocious puberty

Females

Oestradiol. If virilisation is present: Testosterone, Androstenedione, DHEA sulphate.

Ovarian mass

 

  • Granulosa cell tumour

 

  • Thecal cell tumour

 

  • Ovarian follicular cysts (oestrogen-secreting)

 

  • Ovarian tumour (virilising)

 

Hypothyroidism

 

Adrenal tumour

May be feminising or virilising.

Exogenous oestrogens

Ingested as drug, or in adulterated food.

Congenital adrenal hyperplasia (virilising)

17-hydroxyprogesterone.

McCune-Albright syndrome

 

Males

Testosterone, DHEA sulphate, Androstenedione.

Testicular mass

Human chorionic gonadotrophin (beta subunit).

  • Hepatoblastoma

Alpha-fetoprotein.

  • Germ cell tumour

 

  • Leydig cell tumour

 

Hypothyroidism

 

Congenital adrenal hyperplasia

17-hydroxyprogesterone.

McCune-Albright syndrome

 

Familial testotoxicosis

A rare disorder of the LH receptor, with normal androgen levels.