Psychomotor regression

Key Information

Appropriate Tests

 

Psychomotor development is initially normal but deteriorates during infancy or early childhood.

See also Psychomotor retardation

Non-genetic

 

SSPE

See under Measles

Cerebral tumour

 

Hypothyroidism

 

Heavy metal exposure/toxicity, especially

  • Lead poisoning

 

Autoimmune encephalitis

 

Genetic

 

Lysosomal storage diseases

 

Peroxisomal disorders

 

Mitochondrial disorders

 

Rett syndrome

Molecular genetics.

Carbohydrate deficient glycoprotein syndromes

Carbohydrate-deficient transferrin.

Trace elements disease, especially

  • Wilson's disease
  • Menkes disease

 


Copper

Metabolic disease

 

Aminoacidurias, especially

  • Phenylketonuria
  • Lowe syndrome

 

See under Neonatal screening

Organic acidaemias, especially

 

  • Propionic acidaemia

 

Hyperammonaemia

 

Hypoglycaemia

 

Lesch-Nyhan syndrome

Urate, Urate urine.