Sjögren syndrome

Key Information

Appropriate Tests

 

Diagnosis is based on a number of clinical, radiological and pathological criteria, including the presence of Extractable nuclear antigen Ab against Ro (SS-A) and La (SS-B) and the results of labial salivary gland biopsy.

Tests to detect complications include Full blood count, Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, Albumin, Protein electrophoresis, Immunoglobulins G, A, M; Cryoglobulins, serum IgG4.

Presentations/associations

 

Keratoconjunctivitis sicca

See also Sicca syndrome

Xerostomia

 

Connective tissue diseases

 

Lymphadenopathy

  • Reactive
  • Lymphoma (non-Hodgkin)

Lymph node biopsy if malignancy suspected.

Parotid enlargement

  • Parotitis
  • Lymphoma (non-Hodgkin)

Tissue biopsy if malignancy suspected.

See Parotid swelling

Renal tubular acidosis

 

Primary biliary cirrhosis

Mitochondrial Ab.

See under Cirrhosis - cholestasis

Hashimoto thyroiditis

Thyroid Ab, Thyroid stimulating hormone.

See Hashimoto disease