Splenic atrophy/absence

Keywords: Splenectomy, Asplenia, Hyposplenism

Key Information

Appropriate Tests

 

Often detected on the basis of Full blood count and Blood film examination: red cell morphological changes, Thrombocytosis, Leucocytosis.

Causes

 

Post-splenectomy

 

Congenital absence (asplenia)

 

Splenic atrophy/infarction

May be persistent splenomegaly, with haematological findings indicative of reduced splenic function.

  • Myeloproliferative neoplasms

 

  • Irradiation
 
  • Coeliac disease/other malabsorptive disorders

 

  • Dermatitis herpetiformis

 

  • Ulcerative colitis

 

  • Sickle cell anaemia

See Sickle cell disorders.

Consequences

 

Increased susceptibility to infection, especially

See also Infection (increased susceptibility)

  • Streptococcus pneumoniae

 

  • Haemophilus influenzae type B

See Haemophilus influenzae infection.

  • Neisseria meningitidis

See Neisseria meningitidis (meningococcus)

  • Capnocytophaga canimorsus

See Wound infection

  • Cerebral malaria (babesiosus)