Splenomegaly

Causes

Appropriate Tests

 

Review clinical features, including presence of fever, hepatomegaly, lymphadenopathy.

Conditions designated * are typically associated with hepatomegaly also.

Full blood count, Blood film, White cell count differential.

See also Hypersplenism and Hepatomegaly

Infections

 

Viral, especially

  • Infectious mononucleosis*
  • Cytomegalovirus infection
  • HIV infection

 

Bacterial, especially

  • Endocarditis (infective)
  • Septicaemia
  • Typhoid

 

Parasitic, especially

  • Malaria*
  • Leishmaniasis*
  • Schistosomiasis

 

Immune disorders:

SLE

Felty syndrome

 

Disordered splenic blood flow:

Portal hypertension*

Haemolytic anaemia

Autoimmune haemolysis*

Hereditary spherocytosis

Homozygous beta thalassaemia/thalassaemia major*

Haemoglobin H disease*

 

 

 

 


 

See under Thalassaemia
 

See under Thalassaemia

Infiltrative:*

Myeloproliferative neoplasms*

Lymphoma (classification)*

Chronic lymphocytic leukaemia*

Hairy cell leukaemia

Prolymphocytic leukaemia

Amyloidosis*

Lysosomal storage diseases*