Testicular failure

Keywords: Gonodal hypofunction, Gondal hypofunction (male)

Causes

Appropriate Tests

 

Clinical assessment includes testicular site and size, evidence of androgen deficiency and of hypothalamic or pituitary disorder.

Semen analysis - fertility, Follicle stimulating hormone, Luteinising hormone, Prolactin, Testosterone, Testicular biopsy is rarely appropriate.

See also Infertility (male and female)

Hypogonadotrophic hypogonadism (hypothalamic/pituitary disorders)

 

Gonadotrophin releasing hormone deficiency (Kallmann syndrome)

 

Panhypopituitarism

See under Hypopituitarism

Prolactinoma

 

Hereditary haemochromatosis

 

Hypergonadotrophic hypogonadism (primary testicular disorders)

 

Chromosome abnormalities

Cytogenetics - constitutional.

  • Klinefelter syndrome

 

Cryptorchidism

 

Bilateral anorchia

 

Noonan syndrome

 

Vanishing testis syndrome

 

Acquired testicular failure

 

  • Trauma - thermal/physical

 

  • Varicocoele

Usually eugonadotrophic.

  • Cirrhosis

 

  • Renal failure

 

  • Cytotoxic drugs/irradiation

 

  • Viral orchitis

History of Mumps, or other viral infection, associated with Orchitis.

  • Myotonic dystrophy

See under Muscular dystrophy

  • Autoimmune

Sperm Ab.