Ulcerative colitis

Complications

Appropriate Tests

 

Diagnosis based on clinical features and findings on colorectal biopsy.

It is important to exclude infective causes of bloody diarrhoea, especially Campylobacter jejuni, Entamoeba histolytica, Shiga toxin-producing E. coli and Shigella sp.

See Diarrhoea and Inflammatory bowel disease

 

Faecal calprotectin is useful for monitoring disease progression and response to therapy.

Colonic complications

 

Carcinoma colon

See Colorectal tumour.

Toxic megacolon

 

Hepatobiliary disease, especially

Albumin, Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, Gamma glutamyltransferase.

See Hepatitis - Autoimmune

  • Sclerosing cholangitis

See under Cholestasis.

  • Cirrhosis

 

Systemic complications

C-Reactive protein to monitor disease activity

Hypoalbuminaemia

Albumin.

Hypokalaemia

Electrolytes (Potassium).

Anaemia, especially

 

  • Iron deficiency

 

  • Anaemia of chronic disease

 

  • Haemolytic anaemia, especially

Full blood count, Blood film.

Anaemia is usually multifactorial: further investigation guided by initial findings on blood film.

See Haemolysis

  • Salicylazosulphapyridine

Heinz body preparation.

  • Folate deficiency, especially

 

  • Salicylazosulphapyridine

 

Splenic atrophy

 

Erythema nodosum

 

Iritis

 

Pyoderma gangrenosum

 

Arthritis - polyarticular

 

Ankylosing spondylitis