Waldenström's macroglobulinaemia

Keywords: Waldenström macroglobulinaemia (lymphoplasmacytic lymphoma), Lymphoplasmacytic lymphoma

Presentation

Appropriate Tests

 

Waldenström's macroglobulinaemia (WM), lymphoplasmacytic lymphoma, is an indolent lymphoid neoplasm, which occurs mainly in older patients.

It is characterised by the presence of an IgM paraprotein and a bone marrow infiltrate with monoclonal plasmacytoid lymphocytes.

Hyperviscosity and progressive bone marrow failure are common complications of WM.

Full blood count, Blood film, White cell count differential, Erythrocyte sedimentation rate, Bone marrow biopsy (bone marrow aspiration/trephine biopsy), Protein, Albumin, Protein electrophoresis, Paraprotein typing (and quantitation), Immunoglobulins (G, A, M).

See also Lymphoma (classification), Lymphoproliferative disorders and Paraproteinaemia

Hyperviscosity syndrome

 

Splenomegaly

 

Lymphocytosis

 

Anaemia, Neutropenia and Thrombocytopenia

Commonly due to bone marrow infiltration.

Bleeding disorders

Paraproteins may inhibit platelet function and/or fibrin polymerisation (Thrombin time).

Peripheral neuropathy

See Neuropathy