Adrenal Ab

Keywords: Adrenal antibody

Specimen:

5 mL blood in plain tube.

Method:

Indirect IF with primate adrenal substrate.

Reference Interval:

Qualitative test. Positive result is significant.

Application:

Used in diagnosis of autoimmune adrenal failure.

To predict risk of adrenal failure in patients with polyglandular autoimmune syndrome type I.

Interpretation:

Adrenal antibodies are present in 70 % of patients with autoimmune Addison's disease and in < 5 % of those with Addison's disease due to other causes.

May be present in patients with other autoimmune disease.

Reference:

Betterle C et al. Endocr Rev 2002; 23: 327-364.

Erichsen MM et al. J Clin Endrocinol Metab 2009; 94: 4882-4890.