Albumin urine

Keywords: Microalbumin

Specimen:

Random urine samples and Albumin/Creatinine ratio are now preferred.

Patients should refrain from vigorous exercise for 24 h prior to sample collection.

Method:

Immunoassay.

Reference Interval:

Normal:< 30 mg albumin/g creatinine

Microalbuminuria: 30 to 300 mg albumin/g creatinine

Macroalbuminuria: > 300 mg albumin/g creatinine

Application:

Early detection of diabetic nephropathy; investigation and monitoring of renal disease.

Interpretation:

Increased excretion of albumin (> 30 mg/g creatinine) of insufficient degree to be detected by dipstick is an early sign of diabetic nephropathy.

Microalbuminuria (30-300 mg/g creatinine) is an early marker of renal damage that may be progressive if risk factors are not adequately treated.

Urine albumin is elevated in the Nephrotic syndrome, in other conditions with increased glomerular permeability (eg, Glomerulonephritis), and in urinary tract inflammation. It can be used instead of urinary protein to detect or monitor these conditions.

See also Urinalysis.

Reference:

Eknoyan G et al. Am J Kidney Dis 2003; 42: 617-622.