Alpha-1-microglobulin urine

Specimen:

Random urine.

Method:

Immunoassay.

An analyte/creatinine ratio is used to correct for varying dilution of urine.

Reference Interval:

< 15 mg/L; < 1.5 g/mol creatinine.

Application:

Diagnosis of tubular proteinuria (eg, Fanconi syndrome, tubulo-interstitial disorders). This test is preferable to β2-microglobulin as the latter is unstable in acid urine.

Interpretation:

Increased excretion shows the presence of renal tubular disease. Increased levels may be present in the Nephrotic syndrome but this is not invariable.

Reference:

Everaert K et al. Clin Chim Acta 2000; 297: 183-189.