Anti-deoxyribonuclease B Ab

Keywords: Anti-deoxyribonuclease B antibody, Anti-DNase B antibody

Specimen:

5-10 mL blood in plain tube.

Method:

Inhibition of streptococcal DNase B activity.

Reference Interval:

Method dependent.

Application:

Suspected recent infection with Streptococcus pyogenes.

Anti - DNase B antibodies are more sensitive than the ASOT for the diagnosis of post-streptococcal glomerulonephritis and serious streptococcal skin infections eg, necrotising fasciitis.

Interpretation:

High titre indicates recent infection with Streptococcus pyogenes.

The titre peaks at 4-6 weeks, but high levels persist for longer than the ASOT. Often used in conjunction with the ASOT.

See also Antistreptolysin O titre.

Reference:

Martin DR. In: Stevens DL, Kaplan EL. Streptococcal Infections. New York: Oxford University Press, 2000.