B-Type natriuretic peptide

Keywords: BNP

Specimen:

5 mL blood in EDTA tube.

Method:

Immunoassay.

Reference Interval:

< 100 ng/L

Application:

Diagnosis and assessment of severity of heart failure.

Interpretation:

BNP < 100 ng/L Congestive heart failure (CHF) unlikely

BNP 100-500 ng/L Equivocal range

BNP > 500 ng/L Consistent with the diagnosis of CHF

BNP has a shorter half-life than NT-proBNP. Circulating BNP levels are similar to NT-proBNP in normal individuals, but are significantly less elevated by left ventricular dysfunction than NT-proBNP.

BNP levels may be elevated by factors other than CHF, such as acute coronary syndrome, pulmonary embolism, shock, atrial arrhythmia, severe pneumonia and renal disease.

BNP levels are higher in women than men, increase with age and have an inverse relationship with BMI (lower in obesity).

Reference:

Kim HN et al. Circulation 2011; 123: 2015-2019.

Januzzi JL. Eur Heart J 2006; 27: 330-337.

2013 ACCF/AHA Guideline for the Management of Heart Failure. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013; 128: e240-e327.