Bence Jones protein urine

Keywords: Protein electrophoresis urine, Urine EPG, Paraprotein typing urine

Specimen:

Random urine specimen; 24 h urinary collection preferred.

Method:

Protein electrophoresis on urine.

Reference Interval:

Depends on laboratory.

Application:

Investigation of monoclonal gammopathies, hypogammaglobulinaemia, and suspected Plasma cell myeloma.

Performed in conjunction with Protein electrophoresis (serum).

Interpretation:

Monoclonal free light chain proteinuria (Bence Jones proteinuria) is seen in patients with light chain myeloma (where there is a monoclonal expression of the light chain without a coexisting heavy chain), in approximately 50% of those with IgG and IgA myeloma, and in some patients with other Lymphoproliferative disorders (e.g. macro­globulinaemia) and plasma cell dyscrasias (Amyloidosis).

Intact paraprotein molecules may also be detected in serum.

Urine protein dipsticks do not detect Bence Jones protein.

See Free light chains.

Reference:

Beetham R. Ann Clin Biochem 2000; 37: 563-570.