Bordetella pertussis Ab

Keywords: Bordetella pertussis antibody, Bordetella pertussis serology, Pertussis antibody

Specimen:

5-10 mL blood in plain tube

Method:

EIA for IgA antibodies and sometimes other antibody classes to pertussis toxin.

Application:

Suspected pertussis early in the course of the illness, in conjunction with culture or nucleic acid detection after amplification.

Serum antibody test may be useful for retrospective diagnosis.

Interpretation:

Serum IgA antibodies may not become positive until 2 weeks after commencement of symptoms.

IgA antibodies are not stimulated by vaccination, so a positive result in a vaccinated patient indicates past or current infection.

Only a minority of infants develop serum antibodies so the sensitivity of this test is poor.

Reference:

Müller FC et al. J Clin Microbiol 1997; 35: 2435-2443.