Centromere Ab

Keywords: Centromere antibody

Specimen:

5 mL blood in plain tube.

Method:

Indirect IF (part of Antinuclear Ab test).

Line blot and ELISA.

Reference Interval:

Qualitative test. Positive is significant.

Application:

Investigation of systemic rheumatic disease.

Diagnosis of CREST syndrome (limited scleroderma).

May sometimes be associated with primary biliary Cirrhosis.

Interpretation:

Moderately specific, present in 90% of patients with limited scleroderma syndrome.

See also Antinuclear Ab.

Reference:

Spencer-Green G et al. Am J Med 1997; 103(3): 242-248.