Chloride urine

Keywords: Urine chloride, Urine Cl

Specimen:

Random or 24 h urine collection without preservative.

Method:

Spectrophotometry, or ISE.

Reference Interval:

Dependent on intake, typically 100-250 mmol/24 h

Application:

To define the site of chloride loss in metabolic alkalosis and other electrolyte disturbances when it is not obvious clinically. Monitoring compliance with a low salt diet.

Interpretation:

Patients with a metabolic alkalosis and an associated urine chloride level of < 10 mmol/L are usually chloride deficient from gut or sweat loss and may require replacement therapy.

Reference:

Harrington JT and Cohen JJ. N Engl J Med 1975; 293(24): 1241-1243.