Chymotrypsin faeces

Keywords: Trypsin faeces

Description:

See Trypsin faeces.

Specimen:

5 g faeces (random) frozen immediately after collection.

Method:

Spectrophotometry.

Some laboratories may assay trypsin which requires a different substrate.

Both are being replaced by specific assays for human pancreatic elastase. 

See Pancreatic elastase faeces.

Reference Interval:

Method dependent.

Application:

Diagnosis of pancreatic exocrine failure. Assessment of pancreatic enzyme replacement.

Interpretation:

Faecal trypsin and chymotrypsin are reduced in pancreatic exocrine failure.

Malabsorption and decreased faecal enzymes are not usually obvious until >95% of the pancreas has been destroyed.

Reference:

Petersen JM and Forsmark CE. Semin Gastrointest Dis 2002; 13(4): 191-199.

Layer P et al. Curr Gastroenterol Rep 2001; 3(2): 101-108.