Clonazepam

Specimen:

5 mL blood in lithium heparin or plain tube.

The specimen should be taken at least four hours after the last dose.

Method:

HPLC.

Therapeutic Interval:

15-50 µg/L.

Application:

Monitoring clonazepam therapy.

Interpretation:

The drug has a half-life of approximately 40 hours.

Reference:

Nanda RN et al. J Neurol Neurosurg Psychiatry 1977; 40: 538-543.

Epilepsia. 2000; 41:8 6-15. Review.