Collagen crosslink fragments

Keywords: Deoxypyridinoline

Specimen:

Morning fasting 2nd void spot urine or blood.

Method:

Immunoassay.

Results urine NTX or DPD, or plasma CTX are expressed as a ratio with creatinine.

Reference Interval:

Depends on method.

Application:

Diagnosis and monitoring of conditions with increased bone collagen breakdown, especially monitoring of treatment in patients with post­menopausal Osteoporosis and Paget's disease of the bone.

Interpretation:

CTX, DPD and NTX are specific for bone collagen.

If levels are increased it indicates an increase of bone breakdown.

Reference:

Vasikaran S et al. Osteoporosis Int 2011;22(2):391-420