Creatinine clearance Cockcroft and Gault

Keywords: Cr clearance Cockcroft and Gault

Specimen:

Derived from Serum creatinine measurement; see Creatinine urine.

The patient should not eat meat at the meal immediately prior to, or during, the procedure.

Method:

Derived value.

  1. Cockcroft and Gault formula:

  2. Creatinine clearance (mL/min)

    Males = (140-age) x weight (kg) / 0.814 x plasma creatinine (umol/L) Creatinine clearance (mL/min)

    Females = 0.85 x (140-age) x weight (kg) / 0.814 x plasma creatinine (umol/L)

  3. Variations include estimating ideal body weight from patient height in obese subjects.

Reference Interval:

Normal > 70 mL/min in a young adult. Typically falling approx 0.5 mL/min per year at ages over 30 years.

Application:

The Cockcroft and Gault formula for creatinine clearance is recommended as an estimate of glomerular filtration rate (GFR) for assisting with drug dosing decisions in renal impairment. Normalisation for body surface area is not indicated for drug dosing decisions.

Interpretation:

Advice on levels to adjust drug doses available in drug reference sources.

Reference:

Australian Medicines Handbook

Therapeutic Guidelines

MIMS.

Cockcroft DW and Gault MH. Nephron 1976 16: 31-41.