DHEA sulphate

Keywords: DHEAS, Dehydroepiandrosterone sulphate, 17-oxosteriods

Specimen:

5 mL blood in a lithium heparin or plain tube.

Method:

Immunoassay.

Some laboratories measure DHEA, rather than DHEAS.

Reference Interval:

Age dependent.

Adult female, premenopausal: 1-11 µmol/L.

Application:

Investigation of infertility, hirsutism, and virilisation in females.

Interpretation:

Elevated levels indicate an adrenal origin of androgens, typically congenital adrenal hyperplasia or adrenal tumour.

Slight elevations may be of no clinical significance.

Reference:

Siegel SF et al. N Engl J Med. 1990; 323(13): 849-854.