DNA Ab

Keywords: DNA antibody, Deoxyribonuclease souble-stranded antibody, Anti-dsDNA antibody

Specimen:

5 mL blood in plain tube.

Method:

Immunoassay.

Reference Interval:

Method dependent - consult pathologist.

Commonly < 5 IU/mL.

Application:

For confirmation of diagnosis or monitoring of SLE. Sensitivity approximately 70%.

Interpretation:

High levels are strongly suggestive of active SLE, particularly with renal involvement.

Lesser elevations may be found occasionally in other autoimmune disorders.

Reference:

Gill J et al. Am Fam Physician. 2003. 68(11): 2179-2186.