Fibrinogen

Specimen:

4.5 mL blood in 0.5 mL citrate.

Method:

Tests based on thrombin clotting time are in common use.

Also, heat precipitation and immunoassay

Reference Interval:

1.5-4.0 g/L. Some variation with method.

Application:

Investigation of possible acquired or inherited bleeding disorder.

Interpretation:

Low levels indicate reduced production (Liver disease, inherited deficiency) or increased consumption (DIC, Fibrinolysis). Levels are elevated in an acute phase response.

A discrepancy between functional and immunological methods is found in the presence of FDP, and in dysfibrinogenaemia.

Reference:

Exner T et al. Am J Clin Pathol 1979; 71: 521-527.