Free light chains

Keywords: Light chains

Specimen:

5 mL blood in plain tube.

Method:

Immunoassay

Reference Interval:

Consult pathologist

Application:

Diagnosis and monitoring of amyloid, non-secretory myeloma and light chain myeloma. Assessment and monitoring of other forms of myeloma and Monoclonal gammopathy of undetermined significance.

Interpretation:

An excess of kappa over lambda or lambda over kappa light chains is consistent with a plasma cell dyscrasia.

Also see Bence Jones protein urine.

Reference:

Bradwell D et al. Lancet 2003; 36(4): 89-91