Gamma glutamyltransferase

Keywords: GGT, Gamma GT, Gamma glutamyl transpeptidase, GGTP

Specimen:

5 mL blood in lithium heparin or plain tube.

Method:

Spectrophotometry.

Reference Interval:

Male: < 50 U/L

Female: < 30 U/L

Application:

Assessment of Liver disease.

Interpretation:

Increased levels are found in cholestatic liver disease and in hepatocellular disease when there is an element of cholestasis.

Levels are increased in diabetes, NAFLD as a result of enzyme induction from medication ie, phenytoin, and chronic alcohol use.

Pancreatitis and prostatitis may also be associated with increased levels.

Levels may be normal early in the course of acute hepatocellular damage eg, acute viral hepatitis, paracetamol hepatotoxicity.

Reference:

Rochling FA. Clin Cornerstone 2001; 3(6): 1-12.