Gastrin

Keywords: Secretin stimulation test, Intravenous calcium stimulation test

Specimen:

5 mL blood in plain tube.

Patient must be fasting.

Serum should be separated promptly and stored frozen. Ensure patient not on Proton pump inhibitor or Ranitidine.

Method:

Immunoassay.

Reference Interval:

< 100 ng/L.

Application:

Diagnosis of Zollinger-Ellison syndrome.

Interpretation:

If the patient is fasting, and is not taking therapy for peptic ulcer, an elevated level indicates abnormally increased gastrin production.

If the level is 100-500 ng/L, a stimulation test, using either secretin or intravenous calcium, may help to distinguish Zollinger-Ellison syndrome from other causes of hypergastrinaemia eg, atrophic gastritis and pernicious anaemia - consult pathologist.

Reference:

Li ML and Norton JA. Curr Treat Options Oncol 2001; 2(4): 337-346.