Globulins

Specimen:

5 mL blood in plain tube.

Method:

Calculated: globulin = total protein - albumin.

Reference Interval:

Neonate: 12-36 g/L

Adult: 25-35 g/L.

Application:

Identification of hypogammaglobulinaemia and hypergammaglobulinaemia.

Paraproteinaemias are not reliably detected by calculation of total globulin.

Specific measurement of immunoglobulins for deficiencies; and Protein electrophoresis and IFE are preferred for screening for Paraproteinaemia.

Interpretation:

Reference values may differ between racial groups.

Levels are increased with chronic inflammation, infection, autoimmune disease, Liver disease, and Paraproteinaemia.

Levels are decreased in Protein-losing enteropathy, humoral immunodeficiency and sometimes in the Nephrotic syndrome.

Reference:

Silverman LM and Christenson RH. In: Burtis CA and Ashwood ER eds. Tietz Textbook of Clinical Chemistry. 2nd ed. 1994. WB Saunders.