Histone Ab

Keywords: Histone antibody

Specimen:

5 mL blood in plain tube.

Method:

Immunoassay.

Application:

To define specificity of ANA.

Classically histone antibodies give a homogeneous pattern on indirect IF.

Interpretation:

Histone antibodies are of limited value in distinguishing between SLE and drug-induced lupus. Although present in 100% of procainamide-induced lupus they also occur in 20% of patients with SLE.

Reference:

Adams, B et al. Int J Dermatol . 2000; 39:12 887-891.