Immunoglobulins

Keywords: Iggs, Gammaglobulins, IgG, IgA, IgM, Immunoglobulin G, Immunoglobulin A, Immunoglobulin M

Specimen:

5 mL blood in plain tube.

Method:

Immunoassay.

Reference Interval:

Varies with age - see Table 2.

Application:

Assessment of patients with recurrent sinopulmonary infection, sepsis, gastrointestinal infection or other clinical presentations suggestive of immunoglobulin deficiency.

Electrophoresis ± immunofixation is required to exclude the presence of a paraprotein.

Detection of hypogammaglobulinaemia and monitoring immunoglobulin levels in patients with Plasma cell myeloma or Chronic lymphocytic leukaemia.

Interpretation:

Normal immunoglobulin levels do not exclude humoral immunodeficiency.

Further studies, such as assessment of antibody response following administration of vaccines, may be required if there is a high degree of clinical suspicion.

Reference:

Check IJ and Papadea C. In: Rose NR et al eds. Manual of Clinical Laboratory Immunology. 5th ed. 1998.